Ontology highlight
ABSTRACT:
SUBMITTER: Morozov AN
PROVIDER: S-EPMC5000694 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
International journal of molecular sciences 20160809 8
Chloroperoxidase-catalyzed enantiospecific epoxidations of olefins are of significant biotechnological interest. Typical enantiomeric excesses are in the range of 66%-97% and translate into free energy differences on the order of 1 kcal/mol. These differences are generally attributed to the effect of the distal pocket. In this paper, we show that the influence of the proximal pocket on the electron transfer mechanism in the rate-limiting event may be just as significant for a quantitatively accu ...[more]