Ontology highlight
ABSTRACT:
SUBMITTER: Nalairndran G
PROVIDER: S-EPMC7578863 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Nalairndran Geetha G Hassan Abdul Razack Azad A Mai Chun-Wai CW Fei-Lei Chung Felicia F Chan Kok-Keong KK Hii Ling-Wei LW Lim Wei-Meng WM Chung Ivy I Chung Ivy I Leong Chee-Onn CO
Journal of cellular and molecular medicine 20200914 20
Prostate cancer (PCa) is the most common malignancy and is the second leading cause of cancer among men globally. Using a kinome-wide lentiviral small-hairpin RNA (shRNA) library screen, we identified phosphoinositide-dependent kinase-1 (PDPK1) as a potential mediator of cell survival in PCa cells. We showed that knock-down of endogenous human PDPK1 induced significant tumour-specific cell death in PCa cells (DU145 and PC3) but not in the normal prostate epithelial cells (RWPE-1). Further analys ...[more]