Ontology highlight
ABSTRACT:
SUBMITTER: Zhao Z
PROVIDER: S-EPMC5003056 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Zhao Zeguo Z Condomines Maud M van der Stegen Sjoukje J C SJC Perna Fabiana F Kloss Christopher C CC Gunset Gertrude G Plotkin Jason J Sadelain Michel M
Cancer cell 20151001 4
T cell engineering is a powerful means to rapidly generate anti-tumor T cells. The costimulatory properties of second-generation chimeric antigen receptors (CARs) determine the overall potency of adoptively transferred T cells. Using an in vivo "stress test" to challenge CD19-targeted T cells, we studied the functionality and persistence imparted by seven different CAR structures providing CD28 and/or 4-1BB costimulation. One configuration, which uses two signaling domains (CD28 and CD3ζ) and th ...[more]