Ontology highlight
ABSTRACT:
SUBMITTER: Schultz LM
PROVIDER: S-EPMC8812682 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
Schultz Liora M LM Czerwinski Debra K DK Levy Ronald R Levy Shoshana S
Proceedings of the National Academy of Sciences of the United States of America 20220201 5
Adoptive cellular therapy using chimeric antigen receptors (CARs) has revolutionized our treatment of relapsed B cell malignancies and is currently being integrated into standard therapy. The impact of selecting specific T cell subsets for CAR transduction remains under investigation. Previous studies demonstrated that effector T cells derived from naive, rather than central memory T cells mediate more potent antitumor effects. Here, we investigate a method to skew CAR transduction toward naive ...[more]