Ontology highlight
ABSTRACT:
SUBMITTER: Ho R
PROVIDER: S-EPMC5003654 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Nature neuroscience 20160718 9
Modeling amyotrophic lateral sclerosis (ALS) with human induced pluripotent stem cells (iPSCs) aims to reenact embryogenesis, maturation and aging of spinal motor neurons (spMNs) in vitro. As the maturity of spMNs grown in vitro compared to spMNs in vivo remains largely unaddressed, it is unclear to what extent this in vitro system captures critical aspects of spMN development and molecular signatures associated with ALS. Here, we compared transcriptomes among iPSC-derived spMNs, fetal spinal ti ...[more]