Ontology highlight
ABSTRACT:
SUBMITTER: Rossetti S
PROVIDER: S-EPMC5003754 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Rossetti Stefano S Bshara Wiam W Reiners Johanna A JA Corlazzoli Francesca F Miller Austin A Sacchi Nicoletta N
Cancer letters 20160712 2
Regardless of the etiological factor, an aberrant morphology is the common hallmark of ductal carcinoma in situ (DCIS), which is a highly heterogeneous disease. To test if critical core morphogenetic mechanisms are compromised by different mutations, we performed proteomics analysis of five mammary epithelial HME1 mutant lines that develop a DCIS-like morphology in three dimensional (3D) culture. Here we show first, that all HME1 mutant lines share a common protein signature highlighting an inve ...[more]