Ontology highlight
ABSTRACT:
SUBMITTER: Li H
PROVIDER: S-EPMC5578738 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Li Hanqing H Watson Ash A Olechwier Agnieszka A Anaya Michael M Sorooshyari Siamak K SK Harnett Dermott P DP Lee Hyung-Kook Peter HP Vielmetter Jost J Fares Mario A MA Garcia K Christopher KC Özkan Engin E Labrador Juan-Pablo JP Zinn Kai K
eLife 20170815
An 'interactome' screen of all <i>Drosophila</i> cell-surface and secreted proteins containing immunoglobulin superfamily (IgSF) domains discovered a network formed by paralogs of Beaten Path (Beat) and Sidestep (Side), a ligand-receptor pair that is central to motor axon guidance. Here we describe a new method for interactome screening, the Bio-Plex Interactome Assay (BPIA), which allows identification of many interactions in a single sample. Using the BPIA, we 'deorphanized' four more members ...[more]