MiR-422a acts as a tumor suppressor in glioblastoma by targeting PIK3CA.
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ABSTRACT:
SUBMITTER: Liang H
PROVIDER: S-EPMC5004073 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Publications
MiR-422a acts as a tumor suppressor in glioblastoma by targeting PIK3CA.
Liang Haiqian H Wang Renjie R Jin Ying Y Li Jianwei J Zhang Sai S
American journal of cancer research 20160801 8
Although surgical treatment, chemotherapy, and radiotherapy have improved the overall survival rate in glioblastoma multiforme (GBM), further intensive research of GBM's molecular mechanism is still needed. In this study, we observed that miR-422a was downregulated in GBM tissues and cell lines by quantitative real-time polymerase chain reaction (PCR) and primer extension assay. Overexpression of miR-422a significantly reduced the cell proliferation, migration, and invasion of GBM cells. Functio ...[more]
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