MiR-362-3p acts as a tumor suppressor by targeting SERBP1 in ovarian cancer.

ABSTRACT:

Background

Ovarian cancer is the leading lethal gynecological cancer and is generally diagnosed during late-stage presentation. In addition, patients with ovarian cancer still face a low 5-year survival rate. Thus, innovative molecular targeting agents are required to overcome this disease. The present study aimed to explore the function of miR-362-3p and the underlying molecular mechanisms influencing ovarian cancer progression.

Methods

The expression levels of miR-362-3p were determined using qRT-PCR. Gain-of-function and loss-of-function methods were used to detect the effects of miR-362-3p on cell proliferation, cell migration, and tumor metastasis in ovarian cancer. A luciferase reporter assay was performed to confirm the potential target of miR-362-3p, and a rescue exp

SUBMITTER: Cao S 

PROVIDER: S-EPMC7851903 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature