Ontology highlight
ABSTRACT:
SUBMITTER: Ginno PA
PROVIDER: S-EPMC7260214 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Nature communications 20200529 1
DNA methylation is considered a stable epigenetic mark, yet methylation patterns can vary during differentiation and in diseases such as cancer. Local levels of DNA methylation result from opposing enzymatic activities, the rates of which remain largely unknown. Here we developed a theoretical and experimental framework enabling us to infer methylation and demethylation rates at 860,404 CpGs in mouse embryonic stem cells. We find that enzymatic rates can vary as much as two orders of magnitude b ...[more]