Ontology highlight
ABSTRACT:
SUBMITTER: Barber GN
PROVIDER: S-EPMC5004891 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
The rapid detection of microbial agents is essential for the effective initiation of host defence mechanisms against infection. Understanding how cells detect cytosolic DNA to trigger innate immune gene transcription has important implications - not only for comprehending the immune response to pathogens but also for elucidating the causes of autoinflammatory disease involving the sensing of self-DNA and the generation of effective antitumour adaptive immunity. The discovery of the STING (stimul ...[more]