Unknown

Dataset Information

0

Disordered actomyosin networks are sufficient to produce cooperative and telescopic contractility.


ABSTRACT: While the molecular interactions between individual myosin motors and F-actin are well established, the relationship between F-actin organization and actomyosin forces remains poorly understood. Here we explore the accumulation of myosin-induced stresses within a two-dimensional biomimetic model of the disordered actomyosin cytoskeleton, where myosin activity is controlled spatiotemporally using light. By controlling the geometry and the duration of myosin activation, we show that contraction of disordered actin networks is highly cooperative, telescopic with the activation size, and capable of generating non-uniform patterns of mechanical stress. We quantitatively reproduce these collective biomimetic properties using an isotropic active gel model of the actomyosin cytoskeleton, and explore the physical origins of telescopic contractility in disordered networks using agent-based simulations.

SUBMITTER: Linsmeier I 

PROVIDER: S-EPMC5007339 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature

altmetric image

Publications

Disordered actomyosin networks are sufficient to produce cooperative and telescopic contractility.

Linsmeier Ian I   Banerjee Shiladitya S   Banerjee Shiladitya S   Oakes Patrick W PW   Jung Wonyeong W   Kim Taeyoon T   Murrell Michael P MP  

Nature communications 20160825


While the molecular interactions between individual myosin motors and F-actin are well established, the relationship between F-actin organization and actomyosin forces remains poorly understood. Here we explore the accumulation of myosin-induced stresses within a two-dimensional biomimetic model of the disordered actomyosin cytoskeleton, where myosin activity is controlled spatiotemporally using light. By controlling the geometry and the duration of myosin activation, we show that contraction of  ...[more]

Similar Datasets

| S-EPMC3340076 | biostudies-literature
2010-08-24 | E-GEOD-23764 | biostudies-arrayexpress
| S-EPMC8510976 | biostudies-literature
2010-08-24 | GSE23764 | GEO
| S-EPMC3226764 | biostudies-literature
| S-EPMC3896915 | biostudies-literature
| S-EPMC2760528 | biostudies-literature
| S-EPMC3767110 | biostudies-literature
| S-EPMC6369551 | biostudies-literature
| S-EPMC9999349 | biostudies-literature