Ontology highlight
ABSTRACT:
SUBMITTER: Robles AI
PROVIDER: S-EPMC5008065 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Robles Ana I AI Jen Jin J Harris Curtis C CC
Cold Spring Harbor perspectives in medicine 20160901 9
High-throughput sequencing of cancer genomes is increasingly becoming an essential tool of clinical oncology that facilitates target identification and targeted therapy within the context of precision medicine. The cumulative profiles of somatic mutations in cancer yielded by comprehensive molecular studies also constitute a fingerprint of historical exposures to exogenous and endogenous mutagens, providing insight into cancer evolution and etiology. Mutational signatures that were first establi ...[more]