Ontology highlight
ABSTRACT:
SUBMITTER: Douangamath A
PROVIDER: S-EPMC5010360 | biostudies-literature | 2002 Nov
REPOSITORIES: biostudies-literature
Molecular cell 20021101 5
While the function of most small signaling domains is confined to binary ligand interactions, the peroxisomal Pex13p SH3 domain has the unique capacity of binding to two different ligands, Pex5p and Pex14p. We have used this domain as a model to decipher its structurally independent ligand binding sites. By the combined use of X-ray crystallography, NMR spectroscopy, and circular dichroism, we show that the two ligands bind in unrelated conformations to patches located at opposite surfaces of th ...[more]