Ontology highlight
ABSTRACT:
SUBMITTER: Hardie J
PROVIDER: S-EPMC5011398 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Nanotechnology 20160809 37
We report on nanoparticle-stabilized capsules (NPSCs) as a platform for the co-delivery of survivin-targeted siRNA and tamoxifen. These capsules feature an inner oil core that provides a carrier for tamoxifen, and is coated on the surface with positively charged nanoparticles self-assembled with siRNA. The multifaceted chemical nature of the NPSC system enables the simultaneous delivery of both payloads directly into the cytosol in vitro. The NPSC co-delivery of tamoxifen and survivin-targeted s ...[more]