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Dectin-1 predicts adverse postoperative prognosis of patients with clear cell renal cell carcinoma.

ABSTRACT: Dectin-1, a classical pattern-recognition receptor, was now identified as an important regulator in immune homeostasis and cancer immunity through its extensive ligands binding functions and subsequent cytokines production. The aim of this study was to assess the clinical significance of dectin-1 expression in 290 patients with clear cell renal cell carcinoma (ccRCC) through immunohistochemistry on tissue microarrays. We found that dectin-1 was predominantly expressed on ccRCC cells, in accordance with several other online databases. Moreover, Kaplan-Meier method was conducted and high expression of tumoral dectin-1 was associated with shorter patient recurrence free survival (RFS) and overall survival (OS) (P?

SUBMITTER: Xia Y

PROVIDER: S-EPMC5013447 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature

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Dectin-1 predicts adverse postoperative prognosis of patients with clear cell renal cell carcinoma.

Xia Yu Y Liu Li L Bai Qi Q Wang Jiajun J Xi Wei W Qu Yang Y Xiong Ying Y Long Qilai Q Xu Jiejie J Guo Jianming J

Scientific reports 20160907

Dectin-1, a classical pattern-recognition receptor, was now identified as an important regulator in immune homeostasis and cancer immunity through its extensive ligands binding functions and subsequent cytokines production. The aim of this study was to assess the clinical significance of dectin-1 expression in 290 patients with clear cell renal cell carcinoma (ccRCC) through immunohistochemistry on tissue microarrays. We found that dectin-1 was predominantly expressed on ccRCC cells, in accordan ...[more]

PMID: 27600310

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