Enrichment of C5a-C5aR axis predicts poor postoperative prognosis of patients with clear cell renal cell carcinoma.
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ABSTRACT:
SUBMITTER: Xi W
PROVIDER: S-EPMC5348365 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Publications
Enrichment of C5a-C5aR axis predicts poor postoperative prognosis of patients with clear cell renal cell carcinoma.
Xi Wei W Liu Li L Wang Jiajun J Xia Yu Y Bai Qi Q Xiong Ying Y Qu Yang Y Long Qilai Q Xu Jiejie J Guo Jianming J
Oncotarget 20161201 49
Anaphylatoxin C5a and its receptor C5aR on cancer cells constitute a vital axis to cancer progression. In this study, we measured C5aR level by immunohistochemistry in the same cohort of our previous C5a research, and C5a-C5aR axis status was determined by synthesizing C5a and C5aR data. C5aR was an adverse independent prognostic factor for ccRCC patients. Kaplan-Meier analyses revealed the unique position of both C5a and C5aR high population in postoperative survival, based on which patients we ...[more]
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