Ontology highlight
ABSTRACT:
SUBMITTER: Dogbevia GK
PROVIDER: S-EPMC5014524 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Molecular therapy. Nucleic acids 20160412
Controlling gene expression in mammalian brain is of utmost importance to causally link the role of gene function to cell circuit dynamics under normal conditions and disease states. We have developed recombinant adeno-associated viruses equipped with tetracycline-controlled genetic switches for inducible and reversible control of gene expression in a cell type specific and brain subregion selective manner. Here, we characterize a two-virus approach to efficiently and reliably switch gene expres ...[more]