Ontology highlight
ABSTRACT:
SUBMITTER: Shi H
PROVIDER: S-EPMC5005444 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Shi Huwenbo H Kichaev Gleb G Pasaniuc Bogdan B
American journal of human genetics 20160623 1
Variance-component methods that estimate the aggregate contribution of large sets of variants to the heritability of complex traits have yielded important insights into the genetic architecture of common diseases. Here, we introduce methods that estimate the total trait variance explained by the typed variants at a single locus in the genome (local SNP heritability) from genome-wide association study (GWAS) summary data while accounting for linkage disequilibrium among variants. We applied our e ...[more]