Ontology highlight
ABSTRACT:
SUBMITTER: Sun L
PROVIDER: S-EPMC5016164 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Sun Lue L Zhang Yan Y Zhang Zhuqiang Z Zheng Yong Y Du Lilin L Zhu Bing B
The Journal of biological chemistry 20160705 34
Epigenetic systems are well known for the roles they play in regulating the differential expression of the same genome in different cell types. However, epigenetic systems can also directly impact genomic integrity by protecting genetic sequences. Using an experimental evolutionary approach, we studied rates of mutation in the fission yeast Schizosaccharomyces pombe strains that lacked genes encoding several epigenetic regulators or mismatch repair components. We report that loss of a functional ...[more]