Ontology highlight
ABSTRACT:
SUBMITTER: Joyce MG
PROVIDER: S-EPMC5016229 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Joyce M Gordon MG Zhang Baoshan B Ou Li L Chen Man M Chuang Gwo-Yu GY Druz Aliaksandr A Kong Wing-Pui WP Lai Yen-Ting YT Rundlet Emily J EJ Tsybovsky Yaroslav Y Yang Yongping Y Georgiev Ivelin S IS Guttman Miklos M Lees Christopher R CR Pancera Marie M Sastry Mallika M Soto Cinque C Stewart-Jones Guillaume B E GBE Thomas Paul V PV Van Galen Joseph G JG Baxa Ulrich U Lee Kelly K KK Mascola John R JR Graham Barney S BS Kwong Peter D PD
Nature structural & molecular biology 20160801 9
Structure-based design of vaccines, particularly the iterative optimization used so successfully in the structure-based design of drugs, has been a long-sought goal. We previously developed a first-generation vaccine antigen called DS-Cav1, comprising a prefusion-stabilized form of the fusion (F) glycoprotein, which elicits high-titer protective responses against respiratory syncytial virus (RSV) in mice and macaques. Here we report the improvement of DS-Cav1 through iterative cycles of structur ...[more]