Ontology highlight
ABSTRACT:
SUBMITTER: Umitsu M
PROVIDER: S-EPMC5017023 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Umitsu Masataka M Sakai Katsuya K Ogasawara Satoshi S Kaneko Mika K MK Asaki Ryoko R Tamura-Kawakami Keiko K Kato Yukinari Y Matsumoto Kunio K Takagi Junichi J
Scientific reports 20160909
HGF-Met signaling contributes to various biological events by controlling cell migration. Since the abnormal activation of Met receptor causes cancer progression, inhibitors such as neutralizing antibodies are regarded as promising therapeutics. HGF is secreted as a single-chain (sc) precursor and is processed by extracellular proteases to generate disulfide-bonded two-chain (tc) HGF. Although this proteolytic processing of HGF is necessary for its biological activity, exactly how the proteolysi ...[more]