Ontology highlight
ABSTRACT:
SUBMITTER: Wu HQ
PROVIDER: S-EPMC5536358 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Wu Hua-Qing HQ Cheng Mei-Ling ML Lai Jin-Mei JM Wu Hsuan-Hui HH Chen Meng-Chun MC Liu Wen-Huan WH Wu Wu-Hsiung WH Chang Peter Mu-Hsin PM Huang Chi-Ying F CF Tsou Ann-Ping AP Shiao Ming-Shi MS Wang Feng-Sheng FS
PLoS computational biology 20170707 7
The liver is a vital organ involving in various major metabolic functions in human body. MicroRNA-122 (miR-122) plays an important role in the regulation of liver metabolism, but its intrinsic physiological functions require further clarification. This study integrated the genome-scale metabolic model of hepatocytes and mouse experimental data with germline deletion of Mir122a (Mir122a-/-) to infer Warburg-like effects. Elevated expression of MiR-122a target genes in Mir122a-/-mice, especially t ...[more]