Dataset Information

Application of the homology method for quantification of low-attenuation lung region inpatients with and without COPD.

ABSTRACT:

Background

Homology is a mathematical concept that can be used to quantify degree of contact. Recently, image processing with the homology method has been proposed. In this study, we used the homology method and computed tomography images to quantify emphysema.

Methods

This study included 112 patients who had undergone computed tomography and pulmonary function test. Low-attenuation lung regions were evaluated by the homology method, and homology-based emphysema quantification (b₀, b₁, nb₀, nb₁, and R) was performed. For comparison, the percentage of low-attenuation lung area (LAA%) was also obtained. Relationships between emphysema quantification and pulmonary function test results were evaluated by Pearson's correlation coefficients. In addition to the correlation, the patients were divided into the following three groups based on guidelines of the Global initiative for chronic Obstructive Lung Disease: Group A, nonsmokers; Group B, smokers without COPD, mild COPD, and moderate COPD; Group C, severe COPD and very severe COPD. The homology-based emphysema quantification and LAA% were compared among these groups.

Results

For forced expiratory volume in 1 second/forced vital capacity, the correlation coefficients were as follows: LAA%, -0.603; b₀, -0.460; b₁, -0.500; nb₀, -0.449; nb₁, -0.524; and R, -0.574. For forced expiratory volume in 1 second, the coefficients were as follows: LAA%, -0.461; b₀, -0.173; b₁, -0.314; nb₀, -0.191; nb₁, -0.329; and R, -0.409. Between Groups A and B, difference in nb₀ was significant (P-value = 0.00858), and those in the other types of quantification were not significant.

Conclusion

Feasibility of the homology-based emphysema quantification was validated. The homology-based emphysema quantification was useful for the assessment of emphysema severity.

SUBMITTER: Nishio M

PROVIDER: S-EPMC5019166 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Publications

Application of the homology method for quantification of low-attenuation lung region inpatients with and without COPD.

Nishio Mizuho M Nakane Kazuaki K Tanaka Yutaka Y

International journal of chronic obstructive pulmonary disease 20160906

<h4>Background</h4>Homology is a mathematical concept that can be used to quantify degree of contact. Recently, image processing with the homology method has been proposed. In this study, we used the homology method and computed tomography images to quantify emphysema.<h4>Methods</h4>This study included 112 patients who had undergone computed tomography and pulmonary function test. Low-attenuation lung regions were evaluated by the homology method, and homology-based emphysema quantification (<i ...[more]

PMID: 27660430

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Dataset Information

Application of the homology method for quantification of low-attenuation lung region inpatients with and without COPD.

Background

Methods

Results

Conclusion

Publications

Application of the homology method for quantification of low-attenuation lung region inpatients with and without COPD.

Similar Datasets

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