Ontology highlight
ABSTRACT:
SUBMITTER: Desimmie BA
PROVIDER: S-EPMC5027510 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Desimmie Belete A BA Burdick Ryan C RC Izumi Taisuke T Doi Hibiki H Shao Wei W Alvord W Gregory WG Sato Kei K Koyanagi Yoshio Y Jones Sara S Wilson Eleanor E Hill Shawn S Maldarelli Frank F Hu Wei-Shau WS Pathak Vinay K VK
Nucleic acids research 20160720 16
Although APOBEC3 cytidine deaminases A3G, A3F, A3D and A3H are packaged into virions and inhibit viral replication by inducing G-to-A hypermutation, it is not known whether they are copackaged and whether they can act additively or synergistically to inhibit HIV-1 replication. Here, we showed that APOBEC3 proteins can be copackaged by visualization of fluorescently-tagged APOBEC3 proteins using single-virion fluorescence microscopy. We further determined that viruses produced in the presence of ...[more]