Ontology highlight
ABSTRACT:
SUBMITTER: Yao G
PROVIDER: S-EPMC5033645 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Nature structural & molecular biology 20160613 7
Botulinum neurotoxin serotype A1 (BoNT/A1), a licensed drug widely used for medical and cosmetic applications, exerts its action by invading motoneurons. Here we report a 2.0-Å-resolution crystal structure of the BoNT/A1 receptor-binding domain in complex with its neuronal receptor, glycosylated human SV2C. We found that the neuronal tropism of BoNT/A1 requires recognition of both the peptide moiety and an N-linked glycan on SV2. This N-glycan-which is conserved in all SV2 isoforms across verteb ...[more]