Ontology highlight
ABSTRACT:
SUBMITTER: Yelshanskaya MV
PROVIDER: S-EPMC5033713 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Yelshanskaya Maria V MV Singh Appu K AK Sampson Jared M JM Narangoda Chamali C Kurnikova Maria M Sobolevsky Alexander I AI
Neuron 20160908 6
Excitatory neurotransmission plays a key role in epileptogenesis. Correspondingly, AMPA-subtype ionotropic glutamate receptors, which mediate the majority of excitatory neurotransmission and contribute to seizure generation and spread, have emerged as promising targets for epilepsy therapy. The most potent and well-tolerated AMPA receptor inhibitors act via a noncompetitive mechanism, but many of them produce adverse side effects. The design of better drugs is hampered by the lack of a structura ...[more]