Filamentation protects Candida albicans from amphotericin B-induced programmed cell death via a mechanism involving the yeast metacaspase, MCA1.
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ABSTRACT:
SUBMITTER: Laprade DJ
PROVIDER: S-EPMC5036395 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
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Filamentation protects <i>Candida albicans</i> from amphotericin B-induced programmed cell death via a mechanism involving the yeast metacaspase, <i>MCA1</i>.
Laprade David J DJ Brown Melissa S MS McCarthy Morgan L ML Ritch James J JJ Austriaco Nicanor N
Microbial cell (Graz, Austria) 20160701 7
The budding yeast <i>Candida albicans</i> is one of the most significant fungal pathogens worldwide. It proliferates in two distinct cell types: blastopores and filaments. Only cells that are able to transform from one cell type into the other are virulent in mouse disease models. Programmed cell death is a controlled form of cell suicide that occurs when <i>C. albicans</i> cells are exposed to fungicidal drugs like amphotericin B and caspofungin, and to other stressful conditions. We now provid ...[more]
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