Ontology highlight
ABSTRACT:
SUBMITTER: Rius-Perez S
PROVIDER: S-EPMC6405944 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Rius-Pérez Sergio S Tormos Ana M AM Pérez Salvador S Finamor Isabela I Rada Patricia P Valverde Ángela M ÁM Nebreda Angel R AR Sastre Juan J Taléns-Visconti Raquel R
Scientific reports 20190307 1
p38α MAPK negatively regulates the G<sub>1</sub>/S and G<sub>2</sub>/M cell cycle transitions. However, liver-specific p38α deficiency impairs cytokinesis and reduces hepatocyte proliferation during cirrhosis and aging in mice. In this work, we have studied how p38α down-regulation affects hepatocyte proliferation after partial hepatectomy, focusing on mitotic progression, cytokinesis and oxidative stress. We found that p38α deficiency triggered up-regulation of cyclins A1, B1, B2, and D1 under ...[more]