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Associations between explorative dietary patterns and serum lipid levels and their interactions with ApoA5 and ApoE haplotype in patients with recently diagnosed type 2 diabetes.

ABSTRACT: In patients with type 2 diabetes (T2D), responsiveness of serum lipid concentrations to dietary patterns may vary by genotype. The aims of the present study were to identify explorative dietary patterns and to examine their independent associations with serum lipid levels and interactions with apolipoprotein (Apo)A5 and ApoE variants among patients recently diagnosed with T2D.Within a cross-sectional analysis, participants of the German Diabetes Study (n = 348) with mean T2D duration of 6 months were investigated for fasting serum lipid levels, ApoA5 and ApoE genotypes; food consumption frequencies were assessed by a food propensity questionnaire. Dietary patterns were derived using principal component analysis (PCA) and reduced rank regression (RRR), which extracts patterns explaining variation in serum lipid concentrations.PCA yielded interpretable dietary patterns which were, however, not related to serum lipid levels. Relevance of the RRR patterns varied by genotype: a preferred consumption of fruit gum, fruit juice, and potato dumpling, whilst avoiding fruits and vegetables independently associated with higher triglyceride levels among ApoA5*2. Patients in the highest compared to the lowest tertile of pattern adherence had 99 % higher triglycerides. Lower consumption frequencies of butter, cream cake, French fries, or high-percentage alcoholic beverages were independently related to lower LDL-cholesterol among ApoE2 carriers, with those in the highest compared to the lowest tertile of pattern adherence having 40 % lower LDL-cholesterol (both Pinteraction < 0.05).Our explorative data analyses suggest that associations of dietary patterns with triglycerides and LDL-cholesterol differ by ApoA5 and ApoE haplotype in recently diagnosed T2D. Trial registration Clinicaltrials.gov: NCT01055093. Date of registration: January 22, 2010 (retrospectively registered). Date of enrolment of first participant to the trial: September 2005.

SUBMITTER: Weber KS

PROVIDER: S-EPMC5039878 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature

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Associations between explorative dietary patterns and serum lipid levels and their interactions with ApoA5 and ApoE haplotype in patients with recently diagnosed type 2 diabetes.

Weber Katharina S KS Knebel Birgit B Strassburger Klaus K Kotzka Jörg J Stehle Peter P Szendroedi Julia J Müssig Karsten K Buyken Anette E AE Roden Michael M

Cardiovascular diabetology 20160927 1

<h4>Aims</h4>In patients with type 2 diabetes (T2D), responsiveness of serum lipid concentrations to dietary patterns may vary by genotype. The aims of the present study were to identify explorative dietary patterns and to examine their independent associations with serum lipid levels and interactions with apolipoprotein (Apo)A5 and ApoE variants among patients recently diagnosed with T2D.<h4>Methods</h4>Within a cross-sectional analysis, participants of the German Diabetes Study (n = 348) with ...[more]

PMID: 27677442

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Project description:Abstract Objectives The aim of this study was to evaluate serum concentrations of retinol, carotenoids and α-tocopherol before and after 6 mo of an individualized nutrition intervention program in recently diagnosed breast cancer patients (BCP). Methods This is a pretest-posttest study in recently diagnosed nonmetastatic BPC undergoing antineoplastic treatment. Baseline and final measurements include anthropometry, body composition (dual x-ray absorptiometry), 24 h dietary recall, and the assessment of serum retinol, carotenoids and α-tocopherol. The individualized nutrition intervention was developed based on the macronutrient meal equivalent method, based on women's total energy expenditure, and following the WCRF/AICR guidelines, adapting 1.5 g/kg/d of protein intake, 5–9 servings of fruits and vegetables and a caloric restriction (500–1000 kcal/d) when applicable (BMI ≥ 25 kg/m2). Results Nineteen women between 33 and 68 years of age completed the intervention. At the time of diagnosis, 74% of the women were overweight or obese, and serum retinol was < 1.05 µmol/L in 42% (n = 8). After the intervention, BCP decreased an average of 2.67 kg of body weight (p < 0.001), and lost ∼2 kg of body fat (p < 0.01). After the intervention, serum retinol increased + 0.83 µmol/L (p < 0.001) and α-tocopherol increased + 1.89 µmol/L (p < 0.02) increased, which was positively correlated with a dietary increase of these micronutrients (p < 0.05). No difference was found for provitamin A carotenoids or xantophils (α-carotene, β-carotene, β-cryptoxanthin, lutein, zeaxanthin and lycopene) (p > 0.05). Conclusions The implementation of an individualized nutritional intervention program before and during antineoplastic treatment increased serum vitamin A and E concentration, improving the nutritional status of BCP. This trial was registered at clinicaltrials.gov as NCT03625635. Funding Sources JAP, ATLM received a fellowship from the National Research Council in Mexico.

Dataset Information

Associations between explorative dietary patterns and serum lipid levels and their interactions with ApoA5 and ApoE haplotype in patients with recently diagnosed type 2 diabetes.

Publications

Associations between explorative dietary patterns and serum lipid levels and their interactions with ApoA5 and ApoE haplotype in patients with recently diagnosed type 2 diabetes.

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