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ABSTRACT: Objective
To examine the association between nondefect adverse birth outcomes and in utero exposure to zidovudine (ZDV)-containing regimens versus non-ZDV antiretroviral (ARV) regimens.Design
Analysis of prospectively-collected data.Setting
Global.Population
HIV-infected pregnant women prenatally exposed to antiretrovirals.Methods
Estimation of prevalence of and risk for nondefect adverse birth outcomes among HIV-infected women.Main outcome measures
Prevalence of and risk for nondefect adverse birth outcomes.Results
Among 12 780 singleton birth outcomes with in utero ZDV exposure, 96.1% were live births; 3.9% were spontaneous abortions, induced abortions or stillbirths. Among live births, 16.4% were low birthweight (LBW); 12.3% were premature. Among 1904 outcomes with in utero exposure to non-ZDV ARV regimens, 85.8% were live births; 14.2% were spontaneous abortions, induced abortions or stillbirths. Among live births, 14.1% were LBW; 12.4% were premature. Relative risk comparing exposure to ZDV-containing ARV regimens to non-ZDV ARV regimens for spontaneous abortions was 0.18 (95% confidence interval [95% CI] 0.14-0.22); induced abortions 0.28 (95% CI 0.22-0.36); stillbirths 0.76 (95% CI 0.51-1.12); premature births 1.00 (95% CI 0.87-1.15) and LBW 1.17 (95% CI 1.02-1.33).Conclusion
Prevalence of nondefect adverse birth outcomes is lower among outcomes with in utero ZDV exposure versus in utero non-ZDV ARV exposure. The risks for spontaneous and induced abortions were no different for ZDV-containing regimens versus non-ZDV ARV regimens. For premature births and stillbirths, there was no significant difference in risk between the two regimens. The risk of LBW was statistically significantly higher among ZDV-containing regimens versus non-ZDV ARV regimens.Tweetable abstract
ZDV-containing regimens do not increase the risk for nondefect adverse birth outcomes.
SUBMITTER: Vannappagari V
PROVIDER: S-EPMC5042033 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
BJOG : an international journal of obstetrics and gynaecology 20150812 6
<h4>Objective</h4>To examine the association between nondefect adverse birth outcomes and in utero exposure to zidovudine (ZDV)-containing regimens versus non-ZDV antiretroviral (ARV) regimens.<h4>Design</h4>Analysis of prospectively-collected data.<h4>Setting</h4>Global.<h4>Population</h4>HIV-infected pregnant women prenatally exposed to antiretrovirals.<h4>Methods</h4>Estimation of prevalence of and risk for nondefect adverse birth outcomes among HIV-infected women.<h4>Main outcome measures</h ...[more]