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Pestalafuranones F-J, five new furanone analogues from the endophytic fungus Nigrospora sp. BM-2.

ABSTRACT: Five new 2(5H)-furanone-type derivatives, pestalafuranones F-J (compounds 3-7), together with two known compounds, pestalafuranones A (1) and B (2), were isolated from the ethyl acetate extract from the fermentation broth of the endophytic fungus Nigrospora sp. BM-2 in a hypersaline medium. The structures of these metabolites were elucidated by EIMS, HREIMS and NMR spectroscopic data. Compounds 1-7 exhibited no cytotoxic activities against the MDA-MB-231 and Caski cancer cell lines.

SUBMITTER: Zhang H

PROVIDER: S-EPMC6271264 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature

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Pestalafuranones F-J, five new furanone analogues from the endophytic fungus Nigrospora sp. BM-2.

Zhang Hongqi H Deng Zhangshuang Z Guo Zhiyong Z Tu Xuan X Wang Junzhi J Zou Kun K

Molecules (Basel, Switzerland) 20140110 1

Five new 2(5H)-furanone-type derivatives, pestalafuranones F-J (compounds 3-7), together with two known compounds, pestalafuranones A (1) and B (2), were isolated from the ethyl acetate extract from the fermentation broth of the endophytic fungus Nigrospora sp. BM-2 in a hypersaline medium. The structures of these metabolites were elucidated by EIMS, HREIMS and NMR spectroscopic data. Compounds 1-7 exhibited no cytotoxic activities against the MDA-MB-231 and Caski cancer cell lines. ...[more]

PMID: 24434694

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