Ontology highlight
ABSTRACT:
SUBMITTER: Trentin L
PROVIDER: S-EPMC5048141 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Trentin Luca L Bresolin Silvia S Giarin Emanuela E Bardini Michela M Serafin Valentina V Accordi Benedetta B Fais Franco F Tenca Claudya C De Lorenzo Paola P Valsecchi Maria Grazia MG Cazzaniga Giovanni G Kronnie Geertruy Te GT Basso Giuseppe G
Scientific reports 20161004
To induce and sustain the leukaemogenic process, MLL-AF4+ leukaemia seems to require very few genetic alterations in addition to the fusion gene itself. Studies of infant and paediatric patients with MLL-AF4+ B cell precursor acute lymphoblastic leukaemia (BCP-ALL) have reported mutations in KRAS and NRAS with incidences ranging from 25 to 50%. Whereas previous studies employed Sanger sequencing, here we used next generation amplicon deep sequencing for in depth evaluation of RAS mutations in 36 ...[more]