Ontology highlight
ABSTRACT:
SUBMITTER: Richard G
PROVIDER: S-EPMC5048365 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Richard Geoffrey G Dalle Stéphane S Monet Marie-Ambre MA Ligier Maud M Boespflug Amélie A Pommier Roxane M RM de la Fouchardière Arnaud A Perier-Muzet Marie M Depaepe Lauriane L Barnault Romain R Tondeur Garance G Ansieau Stéphane S Thomas Emilie E Bertolotto Corine C Ballotti Robert R Mourah Samia S Battistella Maxime M Lebbé Céleste C Thomas Luc L Puisieux Alain A Caramel Julie J
EMBO molecular medicine 20161004 10
Targeted therapies with MAPK inhibitors (MAPKi) are faced with severe problems of resistance in BRAF-mutant melanoma. In parallel to the acquisition of genetic mutations, melanoma cells may also adapt to the drugs through phenotype switching. The ZEB1 transcription factor, a known inducer of EMT and invasiveness, is now considered as a genuine oncogenic factor required for tumor initiation, cancer cell plasticity, and drug resistance in carcinomas. Here, we show that high levels of ZEB1 expressi ...[more]