Ontology highlight
ABSTRACT:
SUBMITTER: Strub T
PROVIDER: S-EPMC6109055 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Strub Thomas T Ghiraldini Flavia G FG Carcamo Saul S Li Man M Wroblewska Aleksandra A Singh Rajendra R Goldberg Matthew S MS Hasson Dan D Wang Zichen Z Gallagher Stuart J SJ Hersey Peter P Ma'ayan Avi A Long Georgina V GV Scolyer Richard A RA Brown Brian B Zheng Bin B Bernstein Emily E
Nature communications 20180824 1
While multiple mechanisms of BRAF<sup>V600</sup>-mutant melanoma resistance to targeted MAPK signaling inhibitors (MAPKi) have been reported, the epigenetic regulation of this process remains undetermined. Here, using a CRISPR-Cas9 screen targeting chromatin regulators, we discover that haploinsufficiency of the histone deacetylase SIRT6 allows melanoma cell persistence in the presence of MAPKi. Haploinsufficiency, but not complete loss of SIRT6 promotes IGFBP2 expression via increased chromatin ...[more]