Ontology highlight
ABSTRACT:
SUBMITTER: Pascolutti R
PROVIDER: S-EPMC5052120 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Structure (London, England : 1993) 20160908 10
The immune checkpoint receptor PD-1 and its ligand, PD-L1, have emerged as key regulators of anti-tumor immunity in humans. Recently, we reported an ultra-high-affinity PD-1 mutant, termed high-affinity consensus (HAC) PD-1, which shows superior therapeutic efficacy in mice compared with antibodies. However, the molecular details underlying the action of this agent remain incompletely understood, and a molecular view of PD-1/PD-L1 interactions in general is only beginning to emerge. Here, we rep ...[more]