Ontology highlight
ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC6113430 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Li Yanyan Y Liang Zhaoduan Z Tian Ye Y Cai Wenxuan W Weng Zhiming Z Chen Lin L Zhang Huanling H Bao Yifeng Y Zheng Hongjun H Zeng Sihai S Bei Chunhua C Li Yi Y
Cancer science 20180807 8
The inhibitory checkpoint molecule programmed death (PD)-1 plays a vital role in maintaining immune homeostasis upon binding to its ligands, PD-L1 and PD-L2. Several recent studies have demonstrated that soluble PD-1 (sPD-1) can block the interaction between membrane PD-1 and PD-L1 to enhance the antitumor capability of T cells. However, the affinity of natural sPD-1 binding to PD-L1 is too low to permit therapeutic applications. Here, a PD-1 variant with approximately 3000-fold and 70-fold affi ...[more]