A cholinergic-sympathetic pathway primes immunity in hypertension and mediates brain-to-spleen communication.
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ABSTRACT:
SUBMITTER: Carnevale D
PROVIDER: S-EPMC5052663 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Publications
A cholinergic-sympathetic pathway primes immunity in hypertension and mediates brain-to-spleen communication.
Carnevale Daniela D Perrotta Marialuisa M Pallante Fabio F Fardella Valentina V Iacobucci Roberta R Fardella Stefania S Carnevale Lorenzo L Carnevale Raimondo R De Lucia Massimiliano M Cifelli Giuseppe G Lembo Giuseppe G
Nature communications 20160927
The crucial role of the immune system in hypertension is now widely recognized. We previously reported that hypertensive challenges couple the nervous drive with immune system activation, but the physiological and molecular mechanisms of this connection are unknown. Here, we show that hypertensive challenges activate splenic sympathetic nerve discharge to prime immune response. More specifically, a vagus-splenic nerve drive, mediated by nicotinic cholinergic receptors, links the brain and spleen ...[more]
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