Ontology highlight
ABSTRACT:
SUBMITTER: Dhakshnamoorthy B
PROVIDER: S-EPMC5052707 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Dhakshnamoorthy Balasundaresan B Rohaim Ahmed A Rui Huan H Blachowicz Lydia L Roux Benoît B
Nature communications 20160928
The selectivity filter is an essential functional element of K<sup>+</sup> channels that is highly conserved both in terms of its primary sequence and its three-dimensional structure. Here, we investigate the properties of an ion channel from the Gram-positive bacterium Tsukamurella paurometabola with a selectivity filter formed by an uncommon proline-rich sequence. Electrophysiological recordings show that it is a non-selective cation channel and that its activity depends on Ca<sup>2+</sup> con ...[more]