Ontology highlight
ABSTRACT:
SUBMITTER: Kuzu G
PROVIDER: S-EPMC5053140 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Acta crystallographica. Section D, Structural biology 20160920 Pt 10
The structures of protein assemblies are important for elucidating cellular processes at the molecular level. Three-dimensional electron microscopy (3DEM) is a powerful method to identify the structures of assemblies, especially those that are challenging to study by crystallography. Here, a new approach, PRISM-EM, is reported to computationally generate plausible structural models using a procedure that combines crystallographic structures and density maps obtained from 3DEM. The predictions ar ...[more]