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Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk.

ABSTRACT: To identify variants for multiple myeloma risk, we conducted a genome-wide association study with validation in additional series totaling 4,692 individuals with multiple myeloma (cases) and 10,990 controls. We identified four risk loci at 3q26.2 (rs10936599, P = 8.70 × 10(-14)), 6p21.33 (rs2285803, PSORS1C2, P = 9.67 × 10(-11)), 17p11.2 (rs4273077, TNFRSF13B, P = 7.67 × 10(-9)) and 22q13.1 (rs877529, CBX7, P = 7.63 × 10(-16)). These data provide further evidence for genetic susceptibility to this B-cell hematological malignancy, as well as insight into the biological basis of predisposition.

SUBMITTER: Chubb D 

PROVIDER: S-EPMC5053356 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature

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Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk.

Chubb Daniel D   Weinhold Niels N   Broderick Peter P   Chen Bowang B   Johnson David C DC   Försti Asta A   Vijayakrishnan Jayaram J   Migliorini Gabriele G   Dobbins Sara E SE   Holroyd Amy A   Hose Dirk D   Walker Brian A BA   Davies Faith E FE   Gregory Walter A WA   Jackson Graham H GH   Irving Julie A JA   Pratt Guy G   Fegan Chris C   Fenton James Al JA   Neben Kai K   Hoffmann Per P   Nöthen Markus M MM   Mühleisen Thomas W TW   Eisele Lewin L   Ross Fiona M FM   Straka Christian C   Einsele Hermann H   Langer Christian C   Dörner Elisabeth E   Allan James M JM   Jauch Anna A   Morgan Gareth J GJ   Hemminki Kari K   Houlston Richard S RS   Goldschmidt Hartmut H  

Nature genetics 20130818 10

To identify variants for multiple myeloma risk, we conducted a genome-wide association study with validation in additional series totaling 4,692 individuals with multiple myeloma (cases) and 10,990 controls. We identified four risk loci at 3q26.2 (rs10936599, P = 8.70 × 10(-14)), 6p21.33 (rs2285803, PSORS1C2, P = 9.67 × 10(-11)), 17p11.2 (rs4273077, TNFRSF13B, P = 7.67 × 10(-9)) and 22q13.1 (rs877529, CBX7, P = 7.63 × 10(-16)). These data provide further evidence for genetic susceptibility to th  ...[more]

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