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Common variation at 3p22.1 and 7p15.3 influences multiple myeloma risk.

ABSTRACT: To identify risk variants for multiple myeloma, we conducted a genome-wide association study of 1,675 individuals with multiple myeloma and 5,903 control subjects. We identified risk loci for multiple myeloma at 3p22.1 (rs1052501 in ULK4; odds ratio (OR) = 1.32; P = 7.47 × 10(-9)) and 7p15.3 (rs4487645, OR = 1.38; P = 3.33 × 10(-15)). In addition, we observed a promising association at 2p23.3 (rs6746082, OR = 1.29; P = 1.22 × 10(-7)). Our study identifies new genomic regions associated with multiple myeloma risk that may lead to new etiological insights.

SUBMITTER: Broderick P

PROVIDER: S-EPMC5108406 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature

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Common variation at 3p22.1 and 7p15.3 influences multiple myeloma risk.

Broderick Peter P Chubb Daniel D Johnson David C DC Weinhold Niels N Försti Asta A Lloyd Amy A Olver Bianca B Ma Yussanne Y Dobbins Sara E SE Walker Brian A BA Davies Faith E FE Gregory Walter A WA Childs J Anthony JA Ross Fiona M FM Jackson Graham H GH Neben Kai K Jauch Anna A Hoffmann Per P Mühleisen Thomas W TW Nöthen Markus M MM Moebus Susanne S Tomlinson Ian P IP Goldschmidt Hartmut H Hemminki Kari K Morgan Gareth J GJ Houlston Richard S RS

Nature genetics 20111127 1

To identify risk variants for multiple myeloma, we conducted a genome-wide association study of 1,675 individuals with multiple myeloma and 5,903 control subjects. We identified risk loci for multiple myeloma at 3p22.1 (rs1052501 in ULK4; odds ratio (OR) = 1.32; P = 7.47 × 10(-9)) and 7p15.3 (rs4487645, OR = 1.38; P = 3.33 × 10(-15)). In addition, we observed a promising association at 2p23.3 (rs6746082, OR = 1.29; P = 1.22 × 10(-7)). Our study identifies new genomic regions associated with mult ...[more]

PMID: 22120009

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