Ontology highlight
ABSTRACT:
SUBMITTER: Luc S
PROVIDER: S-EPMC5054719 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Cell reports 20160901 12
B cell CLL/lymphoma 11A (BCL11A) is a transcription factor and regulator of hemoglobin switching that has emerged as a promising therapeutic target for sickle cell disease and thalassemia. In the hematopoietic system, BCL11A is required for B lymphopoiesis, yet its role in other hematopoietic cells, especially hematopoietic stem cells (HSCs) remains elusive. The extensive expression of BCL11A in hematopoiesis implicates context-dependent roles, highlighting the importance of fully characterizing ...[more]