Ontology highlight
ABSTRACT:
SUBMITTER: Miloslavski R
PROVIDER: S-EPMC4034726 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Miloslavski Rachel R Cohen Elad E Avraham Adam A Iluz Yifat Y Hayouka Zvi Z Kasir Judith J Mudhasani Rajini R Jones Stephen N SN Cybulski Nadine N Rüegg Markus A MA Larsson Ola O Gandin Valentina V Rajakumar Arjuna A Topisirovic Ivan I Meyuhas Oded O
Journal of molecular cell biology 20140313 3
Cells encountering hypoxic stress conserve resources and energy by downregulating the protein synthesis. Here we demonstrate that one mechanism in this response is the translational repression of TOP mRNAs that encode components of the translational apparatus. This mode of regulation involves TSC and Rheb, as knockout of TSC1 or TSC2 or overexpression of Rheb rescued TOP mRNA translation in oxygen-deprived cells. Stress-induced translational repression of these mRNAs closely correlates with the ...[more]