Ontology highlight
ABSTRACT:
SUBMITTER: Averaimo S
PROVIDER: S-EPMC5059439 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Averaimo Stefania S Assali Ahlem A Ros Oriol O Couvet Sandrine S Zagar Yvrick Y Genescu Ioana I Rebsam Alexandra A Nicol Xavier X
Nature communications 20161003
The development of neuronal circuits is controlled by guidance molecules that are hypothesized to interact with the cholesterol-enriched domains of the plasma membrane termed lipid rafts. Whether such domains enable local intracellular signalling at the submicrometre scale in developing neurons and are required for shaping the nervous system connectivity in vivo remains controversial. Here, we report a role for lipid rafts in generating domains of local cAMP signalling in axonal growth cones dow ...[more]