Ontology highlight
ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC5059635 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Wang Yibo Y Guo Jiqing J Perissinotti Laura L LL Lees-Miller James J Teng Guoqi G Durdagi Serdar S Duff Henry J HJ Noskov Sergei Yu SY
Scientific reports 20161012
Mutations that reduce inactivation of the voltage-gated Kv11.1 potassium channel (hERG) reduce binding for a number of blockers. State specific block of the inactivated state of hERG block may increase risks of drug-induced Torsade de pointes. In this study, molecular simulations of dofetilide binding to the previously developed and experimentally validated models of the hERG channel in open and open-inactivated states were combined with voltage-clamp experiments to unravel the mechanism(s) of s ...[more]