Impact of adjuvant chemoradiation on survival in patients with resectable cholangiocarcinoma.

ABSTRACT:

Background

The ideal adjuvant therapy for resected cholangiocarcinoma remains controversial. National guidelines stratify recommendations based on margin status, though few studies are currently available for reference.

Methods

Data was abstracted on all patients with definitive resections of cholangiocarcinoma at our institution between 2000 and 2013. Adjuvant chemoradiation consisted of 45 Gy delivered to elective nodal regions and 50.4-54 Gy to the surgical bed with concurrent fluoropyrimidine-based chemotherapy. Subgroup analyses were performed delineated by margin status.

Results

Curative resection was performed on 95 patients followed by adjuvant chemoradiation in 23/95 (24%) and observation in 72/95 (76%) with a median follow-up of 21.7 months. For those receiv

SUBMITTER: Dover LL 

PROVIDER: S-EPMC5061024 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature