Ontology highlight
ABSTRACT:
SUBMITTER: Upadhyay A
PROVIDER: S-EPMC5064019 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Upadhyay Awani A Pisupati Aditya A Jegla Timothy T Crook Matt M Mickolajczyk Keith J KJ Shorey Matthew M Rohan Laura E LE Billings Katherine A KA Rolls Melissa M MM Hancock William O WO Hanna-Rose Wendy W
Nature communications 20161012
TRPV ion channels are directly activated by sensory stimuli and participate in thermo-, mechano- and chemo-sensation. They are also hypothesized to respond to endogenous agonists that would modulate sensory responses. Here, we show that the nicotinamide (NAM) form of vitamin B<sub>3</sub> is an agonist of a Caenorhabditis elegans TRPV channel. Using heterologous expression in Xenopus oocytes, we demonstrate that NAM is a soluble agonist for a channel consisting of the well-studied OSM-9 TRPV sub ...[more]