Ontology highlight
ABSTRACT:
SUBMITTER: Sugi Y
PROVIDER: S-EPMC5065231 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Sugi Yutaka Y Takahashi Kyoko K Kurihara Kenta K Nakata Kazuaki K Narabayashi Hikari H Hamamoto Yuji Y Suzuki Makoto M Tsuda Masato M Hanazawa Shigemasa S Hosono Akira A Kaminogawa Shuichi S
PloS one 20161014 10
Immune responses against gut microbiota should be minimized to avoid unnecessary inflammation at mucosal surface. In this study, we analyzed the expression patterns of Toll-interacting protein (Tollip), an inhibitor of TLRs and IL-1 family cytokine-related intracellular signaling, in intestinal epithelial cells (IECs). Comparable mRNA expression was observed in murine small and large IECs (S-IECs and L-IECs). However, Tollip protein was only detected in L-IECs, but not in S-IECs. Similar results ...[more]