Ontology highlight
ABSTRACT:
SUBMITTER: Shepherd DJ
PROVIDER: S-EPMC5067305 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Shepherd Daniel J DJ Tsai Shih-Yen SY O'Brien Timothy E TE Farrer Robert G RG Kartje Gwendolyn L GL
Frontiers in neuroscience 20161018
Ischemic stroke is a leading cause of adult disability, including cognitive impairment. Our laboratory has previously shown that treatment with function-blocking antibodies against the neurite growth inhibitory protein Nogo-A promotes functional recovery after stroke in adult and aged rats, including enhancing spatial memory performance, for which the hippocampus is critically important. Since spatial memory has been linked to hippocampal neurogenesis, we investigated whether anti-Nogo-A treatme ...[more]